|
rs121912654
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of GSTM1 is associated with increased susceptibility for AP, and the GSTP1 Val105Ile SNP is associated with an increased risk for AP in men.
|
27984487 |
2017 |
|
rs1490931437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP9 Phe136Leu/Phe136Phe SNPs (heterozygotes) increases the risk for mild AP (odds ratio, 3.616; 95% confidence interval, 1.151-11.364; P < 0.05), whereas the homozygotic genotype of CASP9 Ala28Val decreases risk for mild AP (odds ratio, 0.296; 95% confidence interval, 0.091-0.963; P < 0.05).
|
27984487 |
2017 |
|
rs142907823
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP9 Phe136Leu/Phe136Phe SNPs (heterozygotes) increases the risk for mild AP (odds ratio, 3.616; 95% confidence interval, 1.151-11.364; P < 0.05), whereas the homozygotic genotype of CASP9 Ala28Val decreases risk for mild AP (odds ratio, 0.296; 95% confidence interval, 0.091-0.963; P < 0.05).
|
27984487 |
2017 |
|
rs5029924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither of these SNPs was associated with susceptibility to AP; however, acute pancreatitis patients who possessed the T allele of rs5029924 were more likely to experience systemic inflammatory response syndrome.
|
25050625 |
2014 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Epistasis analysis revealed that AP susceptibility was increased by interaction between <i>IL23R</i> rs11209026 and <i>TNF</i> rs1800629 (p = 1.205 × 10<sup>-5</sup>; OR<sub>interaction</sub> = 4.031).
|
31044631 |
2019 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Toll-like receptor 4 Asp299Gly polymorphism is associated with the infection of pancreatic necrosis in AP.
|
17414051 |
2007 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In view of the inflammatory nature of acute pancreatitis, we aimed to determine the predictive value of two point mutations in the promoter region at position -550 (H/L variants) and -221 (X/Y variants) of the MBL2 gene, and the Asp299Gly and 119C>A polymorphisms of the TLR4 gene on the occurrence of severe acute pancreatitis (SAP).
|
18288881 |
2008 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.
|
24914392 |
2014 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.
|
24914392 |
2014 |
|
rs5743795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, TLR6 rs5743795 GG genotype patients had a lower risk for severe AP (GG OR, 0.909; P < 0.05).
|
25423559 |
2015 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Mutation p.N34S in SPINK1 may predispose patients to acute pancreatitis, especially in those abusing alcohol, and may promote a more severe course of the disease.
|
26100556 |
2015 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The p.N34S mutation in SPINK1 gene was found more frequently in patients with AP in the Indian population, irrespective of disease etiology and whether the disease was recurrent or not, and was associated with disease onset at an earlier age.
|
24844923 |
2014 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Six children with severe acute pancreatitis had SPINK1 N34S mutations (25%, p<0.05), and 4 were homozygous.
|
25981744 |
2015 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The SPINK1 N34S polymorphism was not associated with the sentinel AP attack, but it substantially increases the risk of recurrent attacks.
|
19888199 |
2010 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The SPINK1 variant p.N34S is overrepresented in patients with acute pancreatitis, but more studies distinguishing between first-time and recurrent acute pancreatitis have to be done to determine whether this is only true for patients with recurrent acute pancreatitis.
|
22228370 |
2012 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The SPINK1 N34S variant is associated with acute pancreatitis.
|
18617776 |
2008 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Patients bearing the N34S G allele exhibited a 10-fold increased risk of developing AP compared with controls, suggesting that the SPINK1 N34S mutation represents an etiologic risk factor for AP in our Mexican pediatric patients.
|
22699143 |
2012 |
|
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
SPINK1 N34S mutation enhances the susceptibility of AP.
|
15782101 |
2005 |
|
rs5707
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The renin rs5707 G (rather than A) allele was associated with AP (P = 0.002), infected necrosis (P = 0.025) and mortality (P = 0.046).
|
24743610 |
2015 |
|
rs5275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the rs5275 polymorphism in the 3'-untranslated region of the COX-2 gene may be used as 1 marker for defining the risk of AP.
|
19820421 |
2010 |
|
rs139635080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs146966861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs61734659
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan.
|
19052022 |
2009 |
|
rs61734659
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs748405415
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |